TABLE 1.

ADAR substrates with editing sites in coding sequences

Cell type	RNA	Base-pairing	Codon changesa	References
Mammalian	gluR-B	Exon/intron	Q/R, R/G	(56, 53)
	gluR-C	Exon/intron	R/G	(53)
	gluR-D	Exon/intron	R/G	(53)
	gluR-5	Exon/intron	Q/R	(56)
	gluR-6	Exon/intron	Q/R, I/V, Y/C	(56, 59)
	Serotonin receptor	Exon/intron	I/V, I/M, N/D, N/S, N/G	(65)
	HDV antigenomeb	Antigenome	Amber/W	(33)
	Measles virus	Unknown	Hypermutation	(85, 121)
	Parainfluenza virus 3	Unknown	Hypermutation	(77)
	Respiratory syncytial virus	Unknown	Hypermutation	(122)
	VSV DI particlec,d	Hairpin	Hypermutation	(78)
	Polyoma virus	Antisense	Hypermutation	(80)
Avian	ALV (retrovirus)e	Hairpinf	Hypermutation	(79)
	RAV-1 (retrovirus)g	Unknown	Hypermutation	(82)
Xenopus	bFGF	Antisense	Hypermutation	(94)
Drosophila	4F rnp	Unknown	Hypermutation	(123)
	Calcium channel (cac)	Exon/intron	S/G, M/I, N/S, M/V, N/G, N/D, R/G	(50, 72)
	Sodium channel (para)	Exon/intron	Q/R, Y/C, M/V, N/D, K/R, N/S	(50, 69, 70)
	Chloride channel	Unknown	I/V, K/R, N/S	(71)
Squid	Potassium channel	Unknown	I/V, Y/C, K/D, M/V, I/M, D/G, S/G	(73)

^aEditing sites are named according to the amino acid change they produce, unedited/edited.

^bHDV, hepatitis delta virus

^cVSV, vesicular stomatitis virus

^dDI, defective-interfering

^eALV, avian leukosis virus

^fThis hairpin is not a natural sequence, but engineered into the retroviral construct.

^gRAV-1, Rous-associated virus type 1