Figure 2.

Specificity of the effect of BDNF in restoring LTP in NCAM knockout mice. (A) Absence of effect of NGF (100 ng/ml) in reversing the LTP defect observed in NCAM knockout mice. The decaying potentiation recorded in slices from NCAM-deficient mice (●, TBS₁) was unaltered by addition of NGF to the slice (bar) and either restimulation of the same pathway (●, TBS₂) or induction of LTP on another naive input (○, TBS₂). Data are mean ± SEM of four experiments. (B) Graph showing the amount of LTP induced in slices prepared from NCAM-deficient mice (●), slices from NCAM-deficient mice, but treated for 30 min either with 100 ng/ml NT4/5 (□) or 200 ng/ml NT4/5. Data are mean ± SEM of 3–4 experiments. (C) Summary of the amount of LTP obtained in slices prepared from wild-type mice (n = 7), NCAM-deficient mice (n = 6), NCAM-deficient mice treated for 30 min with either 100 ng/ml NGF (n = 6), 100 ng/ml NT4/5 (n = 6), or 200 ng/ml NT4/5 (n = 4).