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Urinary-concentrating function in AQP3 single-knockout and AQP3/AQP4 double-knockout mice. (A) Fluid consumption (Upper) and urine output (Lower) over 24 h in mice of indicated genotype (SEM; 16 mice per genotype). (B) Urine osmolalities measured while mice were given free access to food and water before and after DDAVP administration and after a 36-h water deprivation (SEM; 12 mice per genotype). *, P < 0.005 compared with wild-type mouse.
