Figure 5.

Wortmannin administration improved long-term memory in a distributed-training paradigm. Animals were given one session (consisting of three training trials) each day for four consecutive days. Following each daily session, 8.5 ng/hippocampus wortmannin (n = 9) or vehicle (n = 9) was infused. Retention was tested 48 h following the last training session. (A) Daily posttraining administration of wortmannin did not alter the latencies to the platform location during the training or during the transfer test. (B) During the transfer test, animals treated with wortmannin crossed the platform location significantly more times than did animals treated with vehicle. “Counter” areas surrounding the platform location but of larger diameters were also explored significantly longer by the wortmannin-infused animals. Data are presented as the mean ± SEM. P<0.05.