TABLE 6.
Genotypic analysis of the RT mutations that appeared in 22 independently obtained HIV-1(IIIB) mutants in CEM cell cultures
| Mutation | Silent mutation(s)
|
Non-NNRTI-characteristic mutation(s)
|
NNRTI-characteristic mutation(s)
|
|||
|---|---|---|---|---|---|---|
| No.a | Type | No.a | Type | Total no.a | Type (no.) | |
| A → T | 1 | Ala98Ala | 0 | 4 | Lys103Asn (3), Tyr188Leu (1) | |
| C → T | 4 | Phe171Phe | 0 | 2 | Thr139Ile (1), Pro313Ser (1) | |
| T → A | 0 | 0 | 2 | Val179Asp (1), Tyr181Asn (1) | ||
| T → C | 2 | Asn136Asn | 6 | Ile165Thr | 2 | Tyr188His (1), Tyr188Leu (1) |
| G → A | 6 | Glu53Glu, Val111Val | 0 | 9 | Glu138Lys (3), Val108Ile (3), Val189Ile (1), Asp237Asn (1), Arg83Lys (1) | |
| A → G | 1 | Lys275Lys | 0 | 10 | Tyr181Cys (8), Glu138Gly (1), Lys101Glu (1) | |
a
Numbers represent the total number of silent or non-NNRTI-characteristic mutations that emerged through the transition or transversion indicated at the left. No mutations emerged through conversion of guanine to thymine (G → T), cytosine to adenine (C → A), or cytosine to guanine (C → G) or vice versa (T → G, A → C, or G → C).