TABLE 1.
Outcome of 5-day treatment of experimental MRSA aortic valve endocarditis
| Treatment regimen | No. sterile at the following site/total no. of rabbits
|
Mean bacterial count (log10 CFU/g) ± SD
|
||
|---|---|---|---|---|
| Valve vegetation | Kidney | Valve vegetation | Kidney | |
| Control | 0/8 | 0/8 | 10.24 ± 0.68 | 8.66 ± 0.73 |
| Vancomycin | 3/8 | 3/8 | 3.31a,b ± 3.00 | 2.23a ± 2.44 |
| Linezolid t.i.d. for 1 day, for 4 days | 0/8 | 7/8 | 7.80a ± 0.99 | 0.71a ± 2.02 |
| Linezolid plus vancomycin | 0/8 | 8/8 | 6.56a ± 1.03 | 1.00a ± 0.00 |
| Linezolid t.i.d. for 5 days | 0/8 | 3/8 | 6.27a ± 1.80 | 1.75a ± 1.47 |
a
P < 0.05 for all treatment groups versus controls.
b
P < 0.05 for vancomcyin-treated animals versus those treated with linezolid, linezolid and vancomycin, and linezolid t.i.d.