TABLE 2.
Mean concentrations of linezolid in plasma for peak and trough samples
| Linezolid treatment regimen | Day 3 concn (μg/ml) in plasma ± SD at:
|
|
|---|---|---|
| 1 h (peak) | 8 h (trough) | |
| 75 mg/kg t.i.d. for 1 day, b.i.d. for 4 days | 68.63 ± 7.79 | 19.12 ± 3.00 |
| 75 mg/kg t.i.d. for 1 day, b.i.d. for 4 days (with vancomycin) | 43.58a ± 3.65 | 22.76 ± 3.69 |
| 75 mg/kg t.i.d. for 5 days | 70.50 ± 5.75 | 42.56b ± 4.30 |
a
P < 0.05 for linezolid-vancomycin versus linezolid-only regimens.
b
P < 0.05 for linezolid t.i.d. versus linezolid and linezolid-vancomycin regimens.