TABLE 1.
Sequencing results of whole rrs gene analysis in 10 M. tuberculosis isolates having different resistance profiles for KM, AK, and SM
| Clinical isolate of M. tuberculosis | Susceptibility to aminoglycosidea
|
Mutation in the rrs gene | ||
|---|---|---|---|---|
| KM (MIC in μg/ml) | AK (MIC in μg/ml) | SMb | ||
| BTB 02-063 | S (1) | S (≤1) | S | None |
| BTB 02-065 | S (1) | S (≤1) | R | None |
| BTB 02-027 | S (4) | S (≤1) | R | None |
| BTB 02-012 | R (8) | S (≤1) | R | None |
| BTB 02-022 | R (16) | S (≤1) | R | None |
| BTB 02-021 | R (32) | S (≤1) | S | C516T |
| BTB 02-037 | R (32) | S (≤1) | R | None |
| BTB 02-039 | R (32) | S (≤1) | R | None |
| BTB 02-070 | R (64) | R (8) | S | C516T |
| BTB 02-067 | R (>256) | R (>256) | R | A1400G |
a
S, susceptible; R, resistant.
b
Drug concentration used, 4.0 μg/ml.