TABLE 5.
Effect of complementation with wild-type AcrR on fluoroquinolone susceptibility
| Straina | MIC (μg/ml)b
|
|
|---|---|---|
| Norfloxacin | Ciprofloxacin | |
| S5 | >256 | 64 |
| S5/pTS003acrR | 96 | 8 |
| S5/pTS003 | 128 | 64 |
| S10 | >256 | 64 |
| S10/pTS003acrR | 64 | 8 |
| S10/pTS003 | 128 | 64 |
| S13 | >256 | >128 |
| S13/pTS003acrR | 256 | 64 |
| S13/pTS003 | >256 | >128 |
| S36 | >256 | >128 |
| S36/pTS003acrR | 192 | 64 |
| S36/pTS003 | >256 | >128 |
| S7 | 96 | 8 |
| S7/pTS003acrR | 64 | 2 |
| S7/pTS003 | 64 | 8 |
a
pTS003acrR is the vector containing Klebsiella acrR; pTS003 contains the vector only.
b
MIC were determined by E-test (norfloxacin) and doubling agar dilutions (ciprofloxacin).