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Kinetic parameters for TEM-91 β-lactamasea
| Agent | Km (mM) | kcat (s−1) | kcat/Km (M−1 s−1) |
Ki (nM)b
|
|
|---|---|---|---|---|---|
| CLA | SUL | ||||
| Ampicillin | 15.5 | 94.1 | 6.07 × 106 | 34.6 | 33.8 |
| Cephaloridine | 31.6 | 36.3 | 1.15 × 106 | ND | ND |
| Ceftazidime | 179 | 29.0 | 1.62 × 105 | 30.3 | 57.9 |
| Cefotaxime | 32.1 | 2.96 | 9.22 × 104 | ND | ND |
| Aztreonam | 94.8 | 0.0125 | 1.32 × 102 | ND | ND |
Data are mean values from three measurements; each standard deviation was lower than 10%.
Abbreviations: CLA, clavulanic acid; SUL, sulbactam; ND, not done.
