TABLE 1.
Survival of weanling BALB/c mice infected with aerosolized cowpox virus and treated once with aerosolized or s.c.-injected cidofovir on the days indicated relative to the day of infection
| Route of therapy (dose [mg/kg])a | Day of treatment | Survival
|
Pb | |
|---|---|---|---|---|
| No. of animals surviving/total no. of animals | % | |||
| Aero high (0.5-5.0) | −2 | 8/10 | 80 | >0.05 |
| −1 | 9/10 | 90 | >0.05 | |
| 0 | 10/10 | 100 | >0.05 | |
| +1 | 10/10 | 100 | >0.05 | |
| +2 | 9/10 | 90 | >0.05 | |
| Aero low (0.06-0.5) | −2 | 0/10 | 0 | NS |
| −1 | 7/10 | 70 | >0.05 | |
| 0 | 10/10 | 100 | >0.05 | |
| +1 | 9/10 | 90 | >0.05 | |
| +2 | 7/10 | 70 | >0.05 | |
| s.c. (100) | −2 | 7/10 | 70 | >0.05 |
| −1 | 7/10 | 70 | >0.05 | |
| 0 | 10/10 | 100 | >0.05 | |
| +1 | 10/10 | 100 | >0.05 | |
| +2 | 10/10 | 100 | >0.05 | |
| Placebo | 0 | 0/10 | 0 | NS |
a
Aero high, high aerosolized dose; Aero low, low aerosolized dose.
b
Significance was determined by Fisher’s exact comparison of cidofovir-treated animals versus placebo-treated animals. NS, not significant.