TABLE 2.

Numbers of genes regulated in M. tuberculosis by each drug's indicated MIC, according to functional class, at 2 and 6 h^a

Functional classb	Total no. on array	2 h												6 h
		1×-MIC INH		5×-MIC INH		1×-MIC TLM		5×-MIC TLM		1×-MIC TRC		5×-MIC TRC		1×-MIC INH		5×-MIC INH		1×-MIC TLM		5×-MIC TLM		1×-MIC TRC		5×-MIC TRC
		Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down	Up	Down
0: Virulence, detoxification, adaptation	98	1	0	1	0	1	0	1	2	2	0	9	4	0	2	1	4	1	1	0	0	0	1	9	13
1: Lipid metabolism	231	4	1	5	1	14	1	5	0	3	1	11	16	1	0	5	4	8	2	6	3	1	3	13	27
2: Information pathways	224	2	0	0	2	15	3	0	0	2	6	8	49	1	0	1	1	0	2	1	0	0	8	6	60
3: Cell wall and cell processes	699	4	1	3	1	14	4	4	1	14	1	44	24	2	1	14	4	3	4	4	6	9	0	51	33
5: Insertion sequences and phages	141	0	1	0	0	0	3	0	0	2	0	12	1	0	0	1	0	0	0	0	1	2	0	10	1
6: PE/PPE	142	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0
7: Intermediary metabolism and respiration	889	7	7	4	2	17	6	1	5	21	4	54	23	2	2	5	5	0	4	1	2	6	0	54	57
8: Unknown	265	0	4	0	0	3	6	1	1	2	2	10	7	0	0	1	0	0	0	0	0	0	0	32	11
9: Regulatory proteins	186	0	2	1	2	0	1	1	1	2	3	17	2	1	0	1	2	0	1	0	1	1	0	25	4
10: Conserved hypothetical proteins	1,005	7	10	6	2	14	9	1	5	11	7	42	42	2	3	9	4	2	1	4	1	7	0	87	56
Total	3,880	25	26	20	10	78	33	14	15	59	24	207	168	9	8	38	24	14	15	16	14	26	12	288	262

^aINH, isoniazid; TLM, thiolactomycin; TRC, triclosan; Up and Down, up- and downregulated.

^bAccording to TubercuList (http://genolist.pasteur.fr/TubercuList/).