TABLE 2.
Phenotypic analysis of clones C5 and C6 and reference strain HXB2/NL4-3-PR
| Isolate | IC50 (nM)a
|
|||||
|---|---|---|---|---|---|---|
| APV | SQV | IDV | RTV | NFV | LPV | |
| pNL43 | 72.8 ± 6.2 (1) | 3.4 ± 0.45 (1) | 7.3 ± 0.45 (1) | 44.0 ± 3.5 (1) | 48.3 ± 5.8 (1) | 27.13 ± 6.9 (1) |
| Clone C5 | 68.5 ± 5.16 (0.94) | 2.9 ± 0.4 (0.85) | 6.6 ± 0.74 (0.9) | 46.2 ± 3.4 (1) | 39.2 ± 2.9 (0.81) | 19.0 ± 5.2 (0.69) |
| Clone C6 | 70.7 ± 4.3 (0.97) | 2.6 ± 0.37 (0.75) | 6.4 ± 0.37 (0.87) | 42.0 ± 3.5 (0.95) | 32.2 ± 4.2 (0.66) | 9.4 ± 0.52 (0,34) |
a
The values represent the means ± standard deviations of six independent experiments. The values in parentheses are the fold resistance compared to that of strain HXB2/NL4-3-PR abbreviations: APV, amprenavir; SQV, saquinavir; IDV, indinavir; RTV, ritonavir; NFV, nelfinavir; LPV, lopinavir.