TABLE 2.

Effects of various SSG formulations on L. donovani parasite burdens in BALB/c mice^a

Treatment	Mean ± SE parasite burdenb
	Spleen	Liver	Bone marrow
Control	1.49 ± 0.90	3.12 ± 2.24	2.07 ± 1.23
SSG, 222 of mg SbV/kg	1.78 ± 1.30	2.32 ± 2.05	2.14 ± 1.32
SSG-NIV, 222 of mg SbV/kg	0.85 ± 0.60c	1.77 ± 1.36c,d	1.04 ± 0.48c,d
SSG-NIV-dextran, 33 of mg SbV/kg	0.48 ± 0.30c	0.70 ± 0.30c	NDc,e

^aL. donovani-infected mice were treated on day 7 postinfection with a single dose of phosphate-buffered saline (controls), SSG, SSG-NIV, or SSG-NIV-dextran. Normalized parasite burdens were determined on day 14 postinfection.

^bParasite burdens are in mean log LDUs for the spleen and liver and are the mean log number of parasites per 1,000 host cell nuclei for the bone marrow.

^cP < 0.0015 compared to the control treatment.

^dP < 0.01 compared to SSG-NIV-dextran treatment.

^eND, no parasite detected.