TABLE 2.
Treatment | Mean ± SE parasite burdenb
|
||
---|---|---|---|
Spleen | Liver | Bone marrow | |
Control | 1.49 ± 0.90 | 3.12 ± 2.24 | 2.07 ± 1.23 |
SSG, 222 of mg SbV/kg | 1.78 ± 1.30 | 2.32 ± 2.05 | 2.14 ± 1.32 |
SSG-NIV, 222 of mg SbV/kg | 0.85 ± 0.60c | 1.77 ± 1.36c,d | 1.04 ± 0.48c,d |
SSG-NIV-dextran, 33 of mg SbV/kg | 0.48 ± 0.30c | 0.70 ± 0.30c | NDc,e |
L. donovani-infected mice were treated on day 7 postinfection with a single dose of phosphate-buffered saline (controls), SSG, SSG-NIV, or SSG-NIV-dextran. Normalized parasite burdens were determined on day 14 postinfection.
Parasite burdens are in mean log LDUs for the spleen and liver and are the mean log number of parasites per 1,000 host cell nuclei for the bone marrow.
P < 0.0015 compared to the control treatment.
P < 0.01 compared to SSG-NIV-dextran treatment.
ND, no parasite detected.