TABLE 5.

Effects of dosing with different SSG formulations on selected biochemical parameters before dosing and 24 h postdosing^a

Formulation and time of evaluation	AST (U/liter)b	ALT (U/liter)b	Alkaline phosphatase (U/liter)b	Iron (μg/dl)b
Normal level	19-70	28-78	32-185	90-125
SSG
Before dosing	32.25 ± 16.74	56.75± 39.73	83.50 ± 24.28	126.00 ± 51.58
24 h after dosing	33.0 ± 11.05	54.5 ± 16.52	100.75 ± 32.2	141.25 ± 37.2
SSG-dextran
Before dosing	24.25 ± 5.91	32.00 ± 10.98	69.50 ± 28.01	139.00 ± 18.57
24 h after dosing	37.00 ± 12.11	54.50 ± 21.13	81.75 ± 35.27	128.00 ± 27.64
SSG-NIV-dextran
Before dosing	27.25 ± 10.05	40.00 ± 15.38	81.25 ± 32.75	158.75 ± 40.88
24 h after dosing	115.00 ± 90.18	97.50 ± 44.73	214.0 ± 150.90	39.25 ± 10.63

^aDogs (n = 4/group) were given a single intravenous injection of SSG, SSG-dextran, or SSG-NIV-dextran with 10 mg of Sb^V/kg. The normal physiological range for each parameter is shown. The values are means ± SDs.

^bStatistically significant differences between SSG-NIV formulation and the other two formulations.