TABLE 1.
In vitro activity of HMR 1043 and other agents on parental and mutant strainsa
| Organism | Strain | MIC (μg/ml)
|
||||
|---|---|---|---|---|---|---|
| HMR 1043
|
Daptomycin
|
Teicoplanin in MH | ||||
| MH | CSMH | MH | CSMH | |||
| Staphylococcus aureus | ||||||
| Methicillin susceptible ATCC 25923 | 1 | 1 | 0.5 | 0.5 | 0.25 | 1 |
| Methicillin susceptible | 2 | 0.5 | 0.5 | 0.25 | 0.125 | 1 |
| Methicillin susceptible | 2M* | 2 | 1 | 0.25 | 0.125 | 1 |
| Methicillin resistant | 3 | 1 | 0.5 | 0.25 | 0.25 | 1 |
| Teicoplanin intermediate | 4 | 1 | 1 | 0.5 | 0.25 | 16 |
| Teicoplanin intermediate | 4M | 4 | 2 | 1 | 0.25 | 16 |
| VISA | 5 | 4 | 2 | 1 | 0.25 | 16 |
| Staphylococcus epidermidis | ||||||
| Methicillin susceptible ATCC 12228 | 6 | 0.5 | 0.5 | 0.25 | 0.125 | 1 |
| Methicillin susceptible | 6M | 4 | 1 | 0.25 | 0.125 | 2 |
| Methicillin susceptible | 7 | 1 | 0.5 | 0.25 | 0.125 | 1 |
| Methicillin susceptible | 7M | 4 | 2 | 2 | 0.5 | 1 |
| Methicillin resistant | 8 | 1 | 0.5 | 0.25 | 0.125 | 2 |
| Methicillin resistant | 8M | 4 | 2 | 1 | 0.25 | 2 |
| Teicoplanin resistant | 9 | 1 | 1 | 0.25 | 0.125 | 8 |
| Teicoplanin resistant | 9M | 8 | 4 | 2 | 0.5 | 8 |
| Staphylococcus haemolyticus | ||||||
| Teicoplanin susceptible | 10 | 0.5 | 0.5 | 0.125 | 0.125 | 4 |
| Teicoplanin resistant | 11 | 0.5 | 0.5 | 0.25 | 0.125 | 16 |
| Teicoplanin resistant | 11M | 8 | 4 | 0.5 | 0.25 | 16 |
| Enterococcus faecalis ATCC 29212 | 12 | 4 | 2 | 1 | 0.125 | 0.25 |
| VanA 13 | 1 | 0.5 | 2 | 0.25 | 16 | |
| VanB 14 | 4 | 2 | 1 | 0.25 | 0.25 | |
| Enterococcus faecium ATCC 35667 | 15 | 2 | 1 | 2 | 0.25 | 0.5 |
| VanA 16 | 2 | 1 | 2 | 0.5 | >16 | |
| VanB 17 | 4 | 1 | 0.5 | 0.125 | 0.5 | |
| Listeria monocytogenes ATCC 19115 | 18 | 8 | 4 | 4 | 0.5 | 0.5 |
| 18M | >16 | 4 | 4 | 0.5 | 0.5 | |
| 19 | 8 | 2 | 2 | 0.25 | 0.5 | |
| Streptococcus pneumoniae | ||||||
| Penicillin susceptible ATCC 49619 | 20 | 0.125 | 0.125 | 0.125 | 0.03 | 0.125 |
| Penicillin susceptible | 20M | 1 | 1 | 0.125 | 0.06 | 0.125 |
| Penicillin susceptible | 21 | 1 | 0.5 | 0.125 | 0.03 | 0.125 |
| Penicillin susceptible | 21M | 4 | 0.5 | ND | ND | ND |
| Penicillin resistant | 22 | 0.5 | 0.25 | 0.125 | 0.03 | 0.125 |
| Streptococcus pyogenes ATCC 19615 | 23 | 1 | 0.5 | 1 | 0.125 | 0.125 |
| 24 | 1 | 0.5 | 0.06 | 0.03 | 0.125 | |
| Streptococcus agalactiae ATCC 13813 | 25 | 1 | 1 | 0.25 | 0.06 | 0.25 |
| 26 | 1 | 0.5 | 0.25 | 0.06 | 0.125 | |
a
M*, mutant strain with decreased susceptibility; VISA, vancomycin-intermediate Staphylococcus aureus; ND, not determined.