TABLE 2.

Comparison of daptomycin E test MICs and NCCLS broth microdilution MICs according to the Mueller-Hinton agar test medium and E test formulation

Type of M-Hb agar (calcium concn [μg/ml])	E test format	n	No. of isolates with MIC differencec:										% EAa
			−4	−3	−2	−1	Same	+1	+2	+3	+4	+5
BD (50)	Daptod only	350	0	0	1	5	67	246	29	0	2	0	90.9
BD (50)	Dapto + Ca	350	1	10	118	198	22	1	0	0			63.1
Remel (11-14)	Dapto only	50	0	0	0	0	0	0	0	22	26	2	0
Remel (11-14)	Dapto + Ca	50	0	0	2	33	15	0	0	0	0	0	96

^aEA, essential agreement (percentage of MICs within 1 log₂ dilution of the reference MIC).

^bM-H, Mueller-Hinton.

^cDifference values are log₂ dilutions. Negative values indicate that the E test MIC is lower than the broth microdilution MIC.

^dDapto, daptomycin.