FIG. 4.

Effect of atovaquone on bc₁ activity of wild-type (wt) parental and mutant strains. The cytochrome c reductase activity of mitochondrial membranes was measured as described in Materials and Methods in the presence of increasing concentrations of inhibitor. The assays were performed in duplicate, and the results are shown as averages, with less then 10% variation in individual rates. Activities are expressed as a percentage of the turnover number of each strain in the absence of atovaquone.