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Cytochrome c reductase activities of mitochondrial membranes and sensitivity to atovaquone
| Strain | Activity (% of wild type)a | Atovaquone I50 (nM)b |
|---|---|---|
| Wild type | 100 | 50 |
| T127I | 81 | 50 |
| I147V | 67 | 100 |
| T148I | 58 | 100 |
| L150F | 54 | 150 |
| P266L | 45 | 350 |
| L275F | 52 | 400 |
| S152A | 20 | >400 |
The cytochrome c reductase activities were measured as described in Materials and Methods.
The I50 is the concentration of atovaquone required to obtain 50% inhibition of the activity.
