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Wild-type and defective nob-1 first-stage (L1) larvae. Nomarski images are shown with anterior to the left. (a) Wild type. (b) Homozygous ct223 as well as ct351 larvae have the somewhat variable Nob phenotype and terminally arrest development at this stage. (c) Homozygous ct230 larvae show a less severe phenotype, with variably misshapen tails (arrow), and survive to become fertile adults. (d) Heteroallelic animals have intermediate defects and viability.
