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Simulated concentration-time profiles of levofloxacin (free fraction) based on derived pharmacokinetic parameters. (a) Simulated and measured concentrations after administration of the first dose and during steady state for the 1.25-mg/kg dosing regimen; (b and c) simulated concentration-time profiles for the R0 and R11 regimens, respectively, after the administration of a single dose of 10 mg/kg.
