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Relationship between the AUC/MIC ratio and effect for levofloxacin for total drug and the three different regimens. Doses were given every 24, 12, or 6 h (RC regimen) (▪), every 24 h at 0 h and at 1.25 mg/kg every 1 h (R0 regimen) (□), and every 24 h at 11 h and at 1.25 mg/kg every 1 h (R11 regimen) (○). The arrow indicates the peak/MIC ratio where the R0 regimen becomes more efficacious with increasing AUC/MIC ratios.
