TABLE 3.
Metabolite A pharmacokinetics in patients with different renal functions after administration of a 600-mg oral dose of linezolida
| Group | Cmax (μg/ml) | Tmax (h) | AUC0-T (μg · h/ml) | t1/2β (h) | % of dose in urine |
|---|---|---|---|---|---|
| Group 1 | 2.23 ± 0.38 | 6.0 ± 1.3 | 30.5 ± 6.2 | 6.6 ± 2.7 | 44.5 ± 5.2 |
| Group 2 | 3.32 ± 2.44 | 6.7 ± 1.6 | 51.1 ± 38.5 | 9.9 ± 7.4 | 48.7 ± 11.9 |
| Group 3 | 8.64 ± 5.45 | 13.3 ± 4.3 | 203 ± 92 | 11.0 ± 3.9 | 34.5 ± 8.1 |
| Group 4 | |||||
| Off dialysis | 14.0 ± 3.5 | 21.7 ± 9.5 | 467 ± 102 | 72 ± 34 | NA |
| On dialysis | 7.00 ± 0.7 | 21.3 ± 9.9 | 239 ± 44 | 35 ± 22 | NA |
a
Abbreviations: AUC0-T, AUC from time zero to between 24 and 48 h after administration of the dose; t1/2β, apparent elimination half-life; NA, not applicable. The other abbreviations are defined in the text.