TABLE 3.
Results of a Cox proportional hazard model describing independent relations between empirical antimicrobial therapy and risk of death during early follow-upa
Characteristic | Hazard ratio | 95% CI | P value |
---|---|---|---|
Empirical antimicrobial therapy | |||
Adequate combination therapy | 1.0 | ||
Adequate monotherapy | 0.81 | 0.31-2.1 | 0.66 |
Inadequate therapy | 1.2 | 0.29-5.2 | 0.79 |
Age (yr) | |||
<65 | 1.0 | ||
≥65 | 0.22 | 0.06-0.81 | 0.02 |
Clinical presentation | |||
Simple sepsis | 1.0 | ||
Severe sepsis | 31.5 | 3.5-286.4 | 0.002 |
Shock | 38.0 | 5.4-267.8 | <0.001 |
Early follow-up started on the date of bacteremia and extended to the end of the last day before receipt of the antibiogram. Similar results were obtained after exclusion of the 26 patients who had a known urinary or vascular source of P. aeruginosa infection.