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Modeling of probability of fixation (Pfix from equation 2) of fosfomycin-resistant mutants as a function of G/β. s = −0.2 was assumed for the relative growth disadvantage of resistant bacteria to susceptible ones in the absence of the antibiotic. The solid curves show Pfix with uN0 values of 0.001, 0.01, 0.1, and 1 (bottom to top). The dotted curves show the corresponding results if treatment is initiated when the bladder is half full.
