Table 1.
Arterial blood sample analysis and MABP before and after transfusion of solutions of hemoglobin polymer or albumin
Hematocrit, %
|
Hemoglobin, g/dl
|
Paco2, Torr
|
MABP, mmHg
|
|||||
---|---|---|---|---|---|---|---|---|
Pretransfusion | Posttransfusion | Pretransfusion | Posttransfusion | Pretransfusion | Posttransfusion | Pretransfusion | Posttransfusion | |
Hemoglobin groups | ||||||||
Vehicle | 36±3 | 27±4* | 11.0±0.7 | 9.7±1.1* | 37±3 | 37±4 | 95±7 | 94±10 |
WIT-002 | 38±1 | 29±1* | 12.0±0.5 | 10.6±0.2* | 38±2 | 38±2 | 100±4 | 98±4 |
DDMS | 38±2 | 28±4* | 11.9±0.6 | 9.7±1.7* | 37±1 | 39±3 | 97±13 | 100±12 |
HET-0016 | 40±2 | 27±3* | 12.5±0.6 | 10.4±0.9* | 39±1 | 39±3 | 94±4 | 97±5 |
L-NNA | 39±2 | 30±3* | 12.1±0.7 | 10.7±0.8* | 37±2 | 37±2 | 98±8 | 98±9 |
L-NNA + DDMS | 38±2 | 27±2* | 11.6±0.5 | 10.7±0.4 | 37±1 | 37±1 | 95±9 | 97±9 |
Albumin groups | ||||||||
Vehicle | 39±1 | 25±1* | 12.0±0.4 | 7.6±0.3* | 38±2 | 40±3 | 98±5 | 93±6* |
Glibenclamide | 39±2 | 24±2* | 12.1±1.4 | 7.9±0.7* | 39±2 | 40±2 | 99±12 | 97±10 |
Values are means ± SD. Paco2, arterial Pco2; MABP, mean arterial blood pressure; WIT-002, 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid; DDMS, N-methylsulfonyl-12,12-dibromododec-11-enamide; HET-0016, N-hydroxy-N′-(4-butyl-2-methylphenyl)-formamidine; L-NNA, Nω-nitro-L-arginine.
P < 0.05 from pretransfusion by paired t-test.