Figure 2.

WRN increases primer extension by DNA polymerase δ. Indicated amounts of pol δ were mixed with 0.1 pmol of the 14/46 primer/template in the absence or presence of a fixed concentration of WRN (≈6 fmol/10 μl reaction). Reactions were incubated at 37°C for 10 min and were processed as described in the legend to Fig. 1. Lanes: 1, substrate alone; 2, primer/template incubated with ≈6 fmol WRN in the absence of pol δ.