Table 4.
Transmembrane proteins found in only one type of LRO
| Synaptosomes (total 16) |
P21579 - Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)
Q8N9I0 - Synaptotagmin-2 (Synaptotagmin II) (SytII) Q9H2B2 - Synaptotagmin-4 (Synaptotagmin IV) (SytIV) Q5T7P8 - Synaptotagmin-6 (Synaptotagmin VI) (SytVI) O43581 - Synaptotagmin-7 (Synaptotagmin VII) (SytVII) Q86SS6 - Synaptotagmin-9 (Synaptotagmin IX) (SytIX) Q6XYQ8 - Synaptotagmin-10 (Synaptotagmin X) (SytX) Q8IV01 - Synaptotagmin-12 (Synaptotagmin XII) (SytXII) Q7L0J3 - Synaptic vesicle glycoprotein 2A Q8TBG9 - Synaptoporin |
Q7L1I2 - Synaptic vesicle glycoprotein 2B
Q8TAC9 - Secretory carrier-associated membrane protein 5 (Secretory carrier membrane protein 5) Q9UI14 - Prenylated Rab acceptor protein 1 (PRA1 family protein 1) P42658 - Dipeptidyl aminopeptidase-like protein 6 (Dipeptidylpeptidase VI) P50993 - Sodium/potassium-transporting ATPase α-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) P61266 - Syntaxin-1B2 |
| Exosomes (total 16) |
Q13621 - Solute carrier family 12 member 1 (Kidney-specific Na-K-Cl symporter)
Q8NFJ5 - Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Retinoic acid-induced gene 1 protein) O43490 - Prominin-1 precursor (Prominin-like protein 1) Q9NP85 - Podocin Q13113 - PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96) Q9NZH0 - G-protein coupled receptor family C group 5 member B precursor (Retinoic acid-induced gene 2 protein) (RAIG-2) P29972 - Aquaporin-1 (AQP-1) (Aquaporin-CHIP) P41181 - Aquaporin-2 (AQP-2) (Aquaporin-CD) (AQP-CD) (Water channel protein for renal collecting duct) |
P01133 - Pro-epidermal growth factor precursor (EGF)
Q10589 - Bone marrow stromal antigen 2 (BST-2) P12821 - Angiotensin-converting enzyme, somatic isoform precursor (EC 3.4.15.1) O60635 - Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) O15393 - Transmembrane protease, serine 2 precursor (EC 3.4.21.-) P54710 - Sodium/potassium-transporting ATPase γ chain (Na+/K+ ATPase γ subunit) P04439 - HLA class I histocompatibility antigen, A-11 α chain precursor P13746 - HLA class I histocompatibility antigen, A-3 α chain precursor |
| Endosomes (total 35) |
Receptors:
P30559 - Oxytocin receptor (OT-R) P22888 - Luteinizing hormone receptor (LHR) P04629 - High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) P00533 - Epidermal growth factor receptor precursor (EC 2.7.10.1) P01130 - Low-density lipoprotein receptor precursor (LDL receptor) P18825 - α-2C adrenergic receptor (α-2C adrenoceptor) P37288 - Vasopressin V1a receptor (V1aR) P47901 - Vasopressin V1b receptor (V1bR) Q9UP52 - Transferrin receptor protein 2 (TfR2) P51681 - C-C chemokine receptor type 5 (C-C CKR-5) P21462 - fMet-Leu-Phe receptor (fMLP receptor) (N-formyl peptide receptor) (FPR) (N-formylpeptide chemoattractant receptor) Q5VSK2 - Mannose receptor, C type 1-like 1 Others: O15126 - Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1) Q6P5W5 - Zinc transporter ZIP4 precursor (Solute carrier family 39 member 4) O14863 - Zinc transporter 4 (ZnT-4) (Solute carrier family 30 member 4) O95342 - Bile salt export pump (ATP-binding cassette sub-family B member 11) Q9UNQ0 - ATP-binding cassette sub-family G member 2 Q14849 - MLN 64 protein (StAR-related lipid transfer protein 3) (StARD3) (START domain-containing protein 3) |
Q4VX17 - Secretory carrier membrane protein 3
P55073- Type III iodothyronine deiodinase (EC 1.97.1.11) (Type-III 5′ deiodinase) (DIOIII) (Type 3 DI) (5DIII) O95210 - Genethonin-1 (GENX-3414) Q6UWV6 - Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) P56817 - β-secretase 1 precursor (EC 3.4.23.46) (β-site APP cleaving enzyme 1) Q8N4L2 - Transmembrane protein 55A (EC 3.1.3.-) (Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase) Q86T03 - Transmembrane protein 55B (EC 3.1.3.-) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) Q8NFT2 - Six-transmembrane epithelial antigen of prostate 2 (SixTransMembrane protein of prostate 1) (Prostate cancer-associated protein 1) Q9UHE8 - Six transmembrane epithelial antigen of prostate 1 O43493 - Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) O43752 - Syntaxin-6 O14662 - Syntaxin-16 (Syn16) P29016 - T-cell surface glycoprotein CD1b precursor (CD1b antigen) Q9NV92 - NEDD4 family-interacting protein 2 (NEDD4 WW domain-binding protein 5A) Q9GZU1 - Mucolipin-1 (Mucolipidin) (MG-2) Q9UH99 - Sad1/unc-84-like protein 2 (Rab5-interacting protein) Q8NFT8 - d-notch-like EGF repeat-containing transmembrane protein (QPRR262) |
| Lysosomes (total 27) |
transport (GO:0006810):
O60896 - Receptor activity-modifying protein 3 precursor (CRLR activity- modifying protein 3) O60895 - Receptor activity-modifying protein 2 precursor (CRLR activity- modifying protein 2) O60931 - Cystinosin O15431 - High-affinity copper uptake protein 1 (hCTR1) (Copper transporter 1) Q7Z2H8 - Proton-coupled amino acid transporter 1 (Proton/amino acid transporter 1) (Q7Z2H8) Q99571 - P2X purinoceptor 4 (ATP receptor) (P2X4) Q9NRA2 - Sialin (Solute carrier family 17 member 5) (Sodium/sialic acid cotransporter) Q5T465 - Solute carrier family 29 (Nucleoside transporters), member 3 Others including antigen processing, and immune response P13765 - HLA class II histocompatibility antigen, DO β chain precursor (MHC class II antigen DOB) P01903 - HLA class II histocompatibility antigen, DR α chain precursor (MHC class II antigen DRA) P02748 - Complement component C9 precursor P01730 - T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) 9UQV4 - Lysosome-associated membrane glycoprotein 3 precursor (LAMP-3) |
Q13571 - Lysosomal-associated multitransmembrane protein (Retinoic acid- inducible E3 protein) (HA1520)
Q8TEZ7 - Membrane progestin receptor β (mPR β) P07306 - Asialoglycoprotein receptor 1 (ASGPR 1) (ASGP-R 1) (Hepatic lectin H1) Q8WVQ1 - Soluble calcium-activated nucleotidase 1 (EC 3.6.1.6) Q8TBA6 - Golgin subfamily A member 5 (Golgin-84) Q14789 - Golgin subfamily B member 1 (Giantin) (Macrogolgin) Q11201 - CMP-N-acetylneuraminate-β-galactosamide-α-2,3-sialyltransferase (EC 2.4.99.4) P52848 - Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (EC 2.8.2.8) P26572 - α-1,3-mannosyl-glycoprotein 2-β-N-acetylglucosaminyltransferase (EC 2.4.1.101) P19075 - Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor- associated antigen CO-029) O75503 - Ceroid-lipofuscinosis neuronal protein 5 (Protein CLN5) O43291 - Kunitz-type protease inhibitor 2 precursor (Hepatocyte growth factor activator inhibitor type 2) O15455 - Toll-like receptor 3 precursor (CD283 antigen) Q5T021 - Protein tyrosine phosphatase, receptor type, F |
| Platelets (total 24) |
Cell adhesion (GO:0007155) and/or Protein binding (GO:0005515):
P16109 - P-selectin precursor (Granule membrane protein 140) P23229 - Integrin α-6 precursor (VLA-6) (CD49f antigen) P08514 - Integrin α-IIb precursor (Platelet membrane glycoprotein IIb) (GPα IIb) P16284 - Platelet endothelial cell adhesion molecule precursor (PECAM-1) P40197 - Platelet glycoprotein V precursor (GPV) (CD42D antigen) P14770 - Platelet glycoprotein IX precursor (GPIX) (CD42a antigen) P07359 - Platelet glycoprotein Ib α chain precursor (Glycoprotein Ibα) (GP-Ib α) Q15762 - CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1) Q92854 - Semaphorin-4D precursor (Leukocyte activation antigen CD100) Q96AP7 - Endothelial cell-selective adhesion molecule precursor Others: P42857 - Neuron-specific protein family member 1 (Brain neuron cytoplasmic protein 1) Q9UM47 - Neurogenic locus notch homolog protein 3 precursor (Notch 3) |
P55160 - Nck-associated protein 1-like (Membrane-associated protein HEM-1)
Q9Y2A7 - Nck-associated protein 1 (NAP 1) (p125Nap1) (Membrane-associated protein HEM-2) O75352 - Mannose-P-dolichol utilization defect 1 protein (Suppressor of Lec15 and Lec35 glycosylation mutation homolog) Q9HCN6 - Platelet glycoprotein VI precursor Q9P2E5 - Chondroitin sulfate glucuronyltransferase (EC 2.4.1.226) O95870 - Protein BAT5 (HLA-B-associated transcript 5) (Protein G5) O60704 - Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase-2) Q9NYV9 - Taste receptor type 2 member 13 (T2R13) (Taste receptor family B member 3) Q96DZ9 - CKLF-like MARVEL transmembrane domain-containing protein 5 (Chemokine- like factor superfamily member 5) P42892 - Endothelin-converting enzyme 1 (EC 3.4.24.71) Q8TDI7 - Transmembrane cochlear-expressed protein 2 Q53XM7 - VAMP (Vesicle-associated membrane protein)-associated protein B and C |
| Melanosomes (total 181) (partial list here) |
Transporter activity (GO:0005215) and ion channel (GO:0005216):
Q96BI1 - Organic cation transporter-like protein 2 (Imprinted multi-membrane spanning polyspecific transporter-related protein 1) (Solute carrier family 22 member 18) O15438 - Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) P11166 - Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) Q8TDB8 - Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) Q9UP95 - Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) P55011 - Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) P50443 - Sulfate transporter (Diastrophic dysplasia protein) (late stage only) Q96QE2 - Proton myo-inositol cotransporter (H(+)-myo-inositol cotransporter) (Hmit) Q16563 - Synaptophysin-like protein 1 (Pantophysin) P53794 - Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) Q71RS6 - Sodium/potassium/calcium exchanger 5 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 5) (late stage only) P53985 - Monocarboxylate transporter 1 (MCT 1) O15403 - Monocarboxylate transporter 7 (MCT 7) (MCT 6) O15427 - Monocarboxylate transporter 4 (MCT 4) (MCT 3) Q9HD45 - Transmembrane 9 superfamily protein member 3 precursor (SM-11044- binding protein) (EP70-P-iso) Q15904 - Vacuolar ATP synthase subunit S1 precursor (EC 3.6.3.14) (V-ATPase S1 subunit) (V-ATPase S1 accessory protein) (V-ATPase Ac45 subunit) (XAP- 3) P51795 - Chloride channel protein 5 (ClC-5) P51798 - Chloride channel protein 7 (ClC-7) Q13563 - Polycystin-2 (Polycystic kidney disease 2 protein homolog) Q9HBA0 - Transient receptor potential cation channel subfamily V member 4 (TrpV4) Q9Y5S1 - Transient receptor potential cation channel subfamily V member 2 (TrpV2) |
P27449 - Vacuolar ATP synthase 16 kDa proteolipid subunit (EC 3.6.3.14) (late stage only)
Q8IVS1 - Major facilitator superfamily domain containing 1 Q9H2V7 - Spinster-like protein (SPIN1 protein) Q8NCC2 - Solute carrier family 2 (Facilitated glucose transporter), member 6 (late stage only) Q9ULQ1 - KIAA1169 protein Q6P2P0 - Membrane-associated transporter protein, isoform b Q8N169 - Solute carrier family 1 (Glial high affinity glutamate transporter), member 3 Q71UA6 - Neutral amino acid transporter Q14728 - Tetracycline transporter-like protein Transferase activity (GO:0016740): P48651 - Phosphatidylserine synthase 1 (EC 2.7.8.-) (PtdSer synthase 1) (PSS-1) (Serine-exchange enzyme I) Q99735 - Microsomal glutathione S-transferase 2 (EC 2.5.1.18) (Microsomal GST- 2) (Microsomal GST-II) Q14435 - Polypeptide N-acetylgalactosaminyltransferase 3 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 3) Q96L58 - β-1,3-galactosyltransferase 6 (EC 2.4.1.134) (β 3GalT6) (Galactosylxylosylprotein 3-β-galactosyltransferase) O94766 - Galactosylgalactosylxylosylprotein 3-β-glucuronosyltransferase 3 (EC 2.4.1.135) (β-1,3-glucuronyltransferase 3) (Glucuronosyltransferase-I) Q9H553 - α-1,3-mannosyltransferase ALG2 (EC 2.4.1.-) (GDP- Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase) P54764 - Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) P54762 - Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Q16832 - Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Receptor protein-tyrosine kinase TKT) P36897 - TGF-β receptor type-1 precursor (EC 2.7.11.30) (TGF-β receptor type I) (TGFR-1) (TGF-β type I receptor) (Serine/threonine-protein kinase receptor R4) |