Table 4.
Integrin-binding sequence motifs in astrovirus capsid proteins
| Integrin-binding sequence motifs in Astroviral capsid proteins | |||||
| CorePeptide | IntegrinType | CorePeptide | IntegrinType | CorePeptide | IntegrinType |
| RGD | α5,8,vβ1 | LDV | α4β1 | NGR | RGD-like |
| αvβ 3,5,6,8 | low affinity | ||||
| αIIbβ3 | |||||
| AstroVirus | location | AstroVirus | location | AstroVirus | location |
| H1 | VP25 | H1 | VP34 | H1 | VP34 |
| Mink | VP34 | H3 | VP34 | H2 | VP34 |
| Sheep | VP34 | H4 | VP34 | H3 | VP34 |
| H5 | VP34 | H4 | VP34 | ||
| H6 | VP34 | H5 | VP34 | ||
| H7 | VP34 | H6 | VP34 | ||
| H8 | VP34 | H7 | VP34 | ||
| Feline | VP34 | H8 | VP34 & VP25 | ||
| Sheep | VP34 | Feline | VP34 | ||
| Turkey2 | VP25 | Pig | VP34 | ||
| Turkey2 | VP25 | ||||
Sequence motifs (in boldface) are mentioned with the specified subtypes of integrin. The presence of the RDG consensus sequence in human astrovirus serotype 1 was revealed by means of PROSITE. Other putative sequence motifs were traced by text-editing and as yet, experimental support is absent.