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. Author manuscript; available in PMC: 2007 Mar 16.
Published in final edited form as: Pharmacol Ther. 2006 Nov 13;113(1):88–120. doi: 10.1016/j.pharmthera.2006.07.004

Fig. 5.

Fig. 5

Insulin receptor activation and recruitment. An illustration of insulin binding, insulin receptor activation, phosphorylation, recruitment of PI3K, production of PI(3,4,5)P3, and recruitment of Akt with potential inhibition of Akt by the tumor suppressor PTEN. PH refers to the Pleckstrin homology domain of Akt.