Table 3.

ANCOVA of single polymorphism and O⁶-EtGua adduct levels in 171 study subjects

Genotype	N (%)^a	Adduct level^b (adjusted mean ± SE)	% Relative increase	P value^c
*GSTM1*
Wild-type	88 (51.5)	9.13 ± 0.35	Ref.
Null	83 (48.5)	9.22 ± 0.36	+0.98	0.88
*GSTT1*
Wild-type	137 (80.1)	9.42 ± 0.28	Ref.
Null	34 (19.9)	8.20 ± 0.55	−12.9	0.05
*GSTP1* I¹⁰⁵V
I/I	59 (37.1)	9.59 ± 0.43	Ref.
I/V	78 (49.1)	9.12 ± 0.37	− 4.9
V/V	22 (13.8)	8.35 ± 0.71	−12.9	0.32
I/V + V/V	100 (62.9)	8.95 ± 0.34	−6.7	0.24
V allele frequency	0.383
*GSTP1* A¹¹⁴V
A/A	133 (81.6)	9.22 ± 0.28	Ref.
A/V	30 (18.4)	9.26 ± 0.59	+0.43	0.95
V/V	0
V allele frequency	0.092
*MGMT* I¹⁴³V
I/I	119 (69.6)	8.97 ± 0.30	Ref.	.
I/V	50 (29.2)	9.70 ± 0.46	+8.1
V/V	2 (1.2)	8.57 ± 0.31	−4.4	0.40
I/V + V/V	52 (30.4)	9.65 ± 0.45	+7.6	0.21
V allele frequency	0.162
*MGMT* L⁸⁴F
L/L	131 (79.4)	9.38 ± 0.28	Ref.
L/F	34 (20.6)	8.65 ± 0.56	−7.8	0.25
F/F	0
F allele frequency	0.103
*XPD* D³¹²N
D/D	72 (45.3)	9.05 ± 0.38	Ref.
D/N	66 (41.5)	9.21 ± 0.40	+1.8
N/N	21 (13.2)	8.62 ± 0.71	−4.7	0.76
D/N + N/N	87 (54.7)	9.07 ± 0.35	+0.2	0.95
N allele frequency	0.347
*XPD* K⁷⁵¹Q
K/K	70 (40.9)	8.93 ± 0.39	Ref.
K/Q	91 (53.2)	9.50 ± 0.34	+6.9
Q/Q	10 (5.9)	7.94 ± 1.02	−11.1	0.26
K/Q + Q/Q	101 (59.1)	9.34 ± 0.32	+4.6	0.42
Q allele frequency	0.325
*XRCC3* T²⁴¹M
T/T	66 (38.6)	9.12 ± 0.40	Ref.
T/M	75 (43.9)	9.13 ± 0.38	+0.1
M/M	30 (17.5)	9.39 ± 0.60	+2.7	0.86
T/M + M/M	105 (61.4)	9.21 ± 0.32	+1.0	0.87
M allele frequency	0.394

Numbers do not add up to expected totals because of missing genotyping data.

Adduct levels were estimated by ANCOVA for all study subjects, adjusted for age (continuous), sex, smoking status (never-smokers and ever-smokers), and alcohol consumption (never, quit, current).

P value for ANCOVA F-test.