Table 1.
Comparative pathology of old mice (24-26 months of age)
| Caspase-2(+/+) n=29 |
Caspase-2(+/−) n=33 |
Caspase-2(−/−) n=28 |
|
|---|---|---|---|
| Neoplastic lesions | |||
| Lymphoma | 10 | 8 | 4 |
| Lung carcinoma | 6 | 3 | 2 |
| Hepatocellular carcinoma | 1 | 1 | 1 |
| Hemangioma | 2 | 7 | 5 |
| Pheochromocytoma | 0 | 1 | 0 |
| Tumor burden | 0.66 | 0.61 | 0.44 |
| Number of tumor bearing mice | 16(55.2%) | 16(48.5%) | 11(39.3%) |
| Non-neoplastic lesions | |||
| Glomerulonephritis | 26 | 26 | 19 |
| Lymphocyte infiltration | 24 | 23 | 17 |
| Hydronephrosis | 1 | 2 | 2 |
| Acidophilic Macrophage Pn. | 4 | 1 | 1 |
| Psammoma body (brain) | 9 | 9 | 11 |
| EMH (spleen) | 9 | 13 | 2 |
| Angiectasia | 1 | 0 | 1 |
| Arteritis | 1 | 1 | 0 |
Based on histopathology data collected from each mouse, the percentage of tumor-bearing mice, tumor burden and incidence of disease in each group were calculated. The percentage of tumor-bearing mice was calculated as the percentage of mice in an experimental group that had one or more neoplastic lesions. The tumor burden was calculated as the sum of different types of tumor in a mouse.