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. 2007 Mar 20;5(4):e81. doi: 10.1371/journal.pbio.0050081

Figure 8. A Model for Transcriptional Memory.

Figure 8

The long-term repressed state of INO1 and GAL1 localizes randomly within the nucleoplasm and is activated slowly. Upon activation, these genes are recruited to the nuclear periphery through interaction with NPC-associated Nup2, with full transcriptional activation following recruitment. Upon repression, INO1 and GAL1 remain at the nuclear periphery. Specific incorporation of the histone variant H2A.Z into the recently repressed promoter mediates retention at the nuclear periphery and rapid reactivation.