Table 3.
Induction of P-gp expression in CEM and CEMrev cell lines exposed to IINs
| Compound | Concentration | Days of culture | % of P-gp expressing cells | |
| CEM | CEMrev | |||
| None | 0 | 1–3 | ||
| RDS 1974 | 10 μg/ml | 104 | 0 | 25–30 |
| RDS 1983 | 25 μg/ml | 28 | 0 | 7–10 |
| RDS 1984 | 25 μg/ml | 28 | 0 | 15–18 |
| RDS 1996 | 10 μg/ml | 28 | 0 | 17–20 |
| Vinblastine | 10 ng/ml | 28 | ND* | 30–35 |
| 104 | ND* | 60–70 | ||
ND, not done
* % of P-gp expressing cells could not be evaluated due to VBL toxicity. Prolonged and stepwise VBL treatment induced high percentage of P-gp expressing cells [31].