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Tissue histopathology of lungs of mice infected with wild-type, ΔsigM, and ΔsigM-complemented strains of M. tuberculosis. The ΔsigM mutant produces tissue pathology in lungs of infected C57BL/6 mice similar to that with wild-type and complemented strains. C57BL/6 mice infected with ∼102 bacilli by the aerosol route were analyzed at day 1 and at 7, 14, 28, and 56 days (magnification, ×200; hematoxylin and eosin staining).
