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Contribution of IFN-β in endotoxemia. IFN-β is produced by macrophages and induces the expression of several genes, especially chemokines, but also other cytokines. Excessive production of IFN-β may lead to organ damage by overstimulating the production of chemokines that may orchestrate cell migration, which, in collaboration with cytokines and other inflammatory products, can lead to organ damage.
