TABLE 1.
Characteristics of six MAbs produced by immunization with γDPGA in combination with CD40 agonist MAb
| MAb | Immunizing PGA | IgG subclass | VH IMGT subgroup | VH family | JH | D size (no. of residues) | VL IMGT subgroup | VL family | JL | No. of Trp residuesa | Accession no. forb:
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Heavy chain | Light chain | |||||||||||
| 21Bl | B. licheniformis | IgG1 | IGHV10S2*02 | Vh10 | 3 | 5 | IGKV1-135*01 | κ1 | 1 | 6 | EF030733 | EF030739 |
| F24F2 | B. licheniformis | IgG3 | IGHV10S2*02 | Vh10 | 2 | 7 | IGKV1-135*01 | κ1 | 4 | 5 | EF030730 | EF030736 |
| F24G7 | B. licheniformis | IgG3 | IGHV2S4*01 | VhQ52 | 3 | 7 | IGKV1-117*01 | κ1 | 1 | 6 | EF030734 | EF030740 |
| F26G3 | B. licheniformis | IgG3 | IGHV10S2*02 | Vh10 | 4 | 7 | IGKV1-135*01 | κ1 | 2 | 6 | EF030731 | EF030737 |
| F26G4 | B. licheniformis | IgG3 | IGHV5S18*01 | Vh7183 | 2 | 7 | IGKV1-135*01 | κ1 | 1 | 5 | EF030735 | EF030741 |
| F30D1 | B. anthracis | IgG3 | IGHV10S2*02 | Vh10 | 3 | 3 | IGKV6-15*01 | κ19/28 | 5 | 4 | EF030732 | EF030738 |
a
Number of tryptophan residues in MAb binding region.
b
Accession numbers are from the GenBank database.