TABLE 2.
Nramp1 genotype distribution among controlsa
| Genotype | Frequencies of seronegative animals
|
|
|---|---|---|
| Observed | Expected (formula for expected frequency) | |
| AA | 68 | 68 (n × p2) |
| AB | 73 | 68 (n × 2pq) |
| AC | 21 | 27 (n × 2pr) |
| AD | 42 | 41 (n × 2ps) |
| BB | 13 | 17 (n × q2) |
| BC | 11 | 13 (n × 2qr) |
| BD | 24 | 20 (n × 2qs) |
| CC | 5 | 3 (n × r2) |
| CD | 11 | 8 (n × 2rs) |
| DD | 3 | 6 (n × s2) |
| Total | 271 | 271 |
a
p, q, r, and s indicate the observed frequencies of the Nramp1A, -B, -C, and -D alleles, respectively. p = (AA + AB/2 + AC/2 + AD/2)/n = 0.50; q = (BB + AB/2 + BC/2 + BD/2)/n = 0.25; r = (CC + AC/2 + BC/2 + DC/2)/n = 0.10; s = (DD + AD/2 + BD/2 + CD/2)/n = 0.15. n (number of observed animals) = 271. Degrees of freedom (DF) were calculated according to the formula k(k-1)/2, where k is the number of alleles (39). χ2 = {∑[(observed frequency − expected frequency)2/expected frequency]} = 8.9; DF = 6; P = 0.20.