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Comparison of the binding of the LOS-specific IgG preparations (8532V, 35E, 1291, and 6940) to meningococcal strain 7994 (L1,8) and to the LOS mutant 7994-ΔgalE as determined by ELISA. Microtiter wells were coated with whole bacteria and reacted with 10 μg/ml of the IgG. 7994 expresses two major LOS molecules, L1 (α chain structure, Galα1→4Galβ1→4Glcβ1→4Hep1→KDO) and L8 (Galβ1→4Glcβ1→4Hep1→KDO). The mutant expresses LOS with an α chain structure that is truncated to Glcβ1→4Hep1→KDO.
