FIG. 3.

SseL is required for virulence during infection of mice. Groups of susceptible (A) and resistant (B) mice were infected orally with a mixed inoculum containing wild-type (wt) Salmonella and the ΔsseL strain. The CIs for the mutant strains were determined in the spleen and liver at day 3 after infection. Each data point (filled circles) represents one animal, and horizontal bars indicate geometric means. C57BL/6 sseL CI, P < 0.001 (spleen and liver); 129/sv sseL CI, P < 0.0002 (spleen and liver). Open squares indicate the mean CI for the wild-type sseL reversion strain (CI for spleen, 0.93 ± 0.13, P = 0.67; CI for liver, 0.88 ± 0.12, P = 0.40).