TABLE 2.
Mean cytokine and chemokine levels in BALF
| Cytokine or chemokine | Mouse strain | Concn(pg/ml) (mean ± SEM) at the following times postinfectiona:
|
||
|---|---|---|---|---|
| 0 h | 24 h | 48 h | ||
| IL-12p70b | CD1 | NDc | ND | 23 ± 9 |
| C57BL/6 | ND | ND | ND | |
| TNF-αb | CD1 | ND | 5 ± 5 | 533 ± 133 |
| C57BL/6 | ND | ND | 356 ± 75 | |
| IFN-γb | CD1 | ND | ND | 53 ± 35 |
| C57BL/6 | ND | ND | ND | |
| MCP-1b | CD1 | ND | ND | 134 ± 63 |
| C57BL/6 | ND | ND | 110 ± 40 | |
| IL-10b | CD1 | 10 ± 10 | 36 ± 2 | 19 ± 7 |
| C57BL/6 | 12 ± 12 | 39 ± 1 | 18 ± 2 | |
| IL-6b | CD1 | ND | 16 ± 9 | 2,187 ± 563 |
| C57BL/6 | ND | 5 ± 5 | 2,820 ± 358 | |
| MIP-2b | CD1 | ND | 24 ± 9 | 2,198 ± 569 |
| C57BL/6 | ND | 7 ± 5 | 1,821 ± 287 | |
| KCd | CD1 | ND | 32 ± 14 | 3,830 ± 679 |
| C57BL/6 | ND | ND | 1,548 ± 352e | |
a
The data were obtained using 8 to 10 mice.
b
Values were determined using a cytometric bead assay (BD Bioscience).
c
ND, not detected.
d
Values were determined using an ELISA (R&D Systems).
e
The value is significantly different (P < 0.05) from the value obtained for KC in CD1 mice at 48 h.