FIG. 5.

PHA-induced IFN-γ production of PBMCs was strongly suppressed in patients with untreated TB compared to that in controls. In contrast to the results from M. tuberculosis-specific stimulation, no increased IFN-γ production during anti-TB therapy was observed. There was overall no significant difference between mild-to-moderate TB patients and advanced-TB patients (see text; not shown). Each dot in the cross-sectional study represents one individual. A horizontal bar indicates the median in each group. A dashed line indicates the lower detection limit of the assay. Statistically significant differences (P < 0.05) are indicated by asterisks (Mann-Whitney U test).