FIG. 6.
Lesion differences in transgenic infected C57BL/6 and CCR2 KO mice. (A and B) C57BL/6 mice were infected with 5 × 106 wild-type (Lm-WT, •) or transgenic (Lm-Tg, ○) L. major, and lesion development was measured at various time points (indicated in panel A). (C and D) CCR2 KO mice were similarly infected with wild-type (▪) or transgenic (□) L. major and compared to infections with transgenic L. major in C57BL/6 mice (○). Parasite numbers were quantitated at day 31 for C57BL/6 mice (B) and at day 51 for the CCR2 KO mice (D). Error bars represent the standard error of the mean of two (panel C) or three (panel A) separate experiments done with a minimum of five mice per group. *, P < 0.05; **, P < 0.01.