FIG. 9.

Parasite levels in the ears of C57BL/6 and CCR2 KO mice. (A) Parasite numbers in the ears of C57BL/6 mice were determined at various time points after infection with 5 × 10⁴ wild-type L. major (Lm-WT, •) or transgenic L. major (Lm-Tg, ○) parasites. (B and C) Intracellular parasites within sorted CCR2-positive macrophages isolated from the ears of C57BL/6 mice, 21 days after infection with wild-type (B) or transgenic (C) L. major parasites. (D) Parasite numbers in the ears of CCR2 KO mice were determined at weekly intervals after infection with 5 × 10⁴ Lm-WT (•, not visible) or transgenic L. major parasites (○). (E and F) Intracellular parasites within macrophages isolated from the ears of CCR2 KO mice, 21 days after infection with wild-type (E) or transgenic (F) L. major parasites. **, P < 0.01.