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Ploidy-dependent phenotypes of CdtB. (A) CdtB-induced growth defects are severe in haploid (BY4740 and W303-1A) but not in diploid (BY4743 and W303) yeast cells. The HO endonuclease (HO)-induced growth defect was also found to be strain dependent but not ploidy dependent. (B) CdtB induces slow S-phase progression, G2/M arrest, and the accumulation of overreplicated cells with a higher DNA content in haploid but not in diploid strains.
