FIG. 7.

Chimeric PyMSP-1/8 vaccine immunization fails to protect against nonlethal P. yoelii 17X malaria. BALB/cByJ mice (n = 10) were immunized with rPyMSP-8 (▪) (10 μg) or rPyMSP1/8 (▾) (14 μg) formulated with Quil A as an adjuvant or with Quil A alone (⋄). Two weeks following the third immunization, mice were challenged with the nonlethal, reticulocyte-restricted 17X strain of P. yoelii. Percent survival (A) and mean parasitemia (B) in each experimental group are plotted versus days postinfection. Parasitemia was monitored as described above.