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. 2006 Dec 18;75(3):1335–1342. doi: 10.1128/IAI.01203-06

FIG. 4.

FIG. 4.

Supplementation of HMC cultures with BMMφ. (A) A total of 150,000 HMC were added to cultures containing 30,000 BMMφ, and the cultures were challenged with F. tularensis LVS in vitro at the indicated MOI. (B and C) Neutralizing anti-IL-12 or anti-IL-18 was added to cultures just prior to challenge with F. tularensis LVS at an MOI of 61. (B) The IFN-γ values for antibody-treated cultures were significantly different from those for the IgG controls at all antibody concentrations (P < 0.05). (C) The IL-12p70 values for cultures treated with each concentration of anti-IL-12 were significantly different from those for the IgG controls (P < 0.05).