TABLE 3.
Variants of the glycosyltransferases involved in the synthesis of the LOS outer core structures in C. jejuni strains with a class A or B LOS locusa
| Strain | LOS class | Variant
|
|||||
|---|---|---|---|---|---|---|---|
| Cj1135 | Cj1136 | CgtAI | CgtAII | CgtB | CstIIb | ||
| GB2 | A | One domain | On | Monosialylatedc | NAd | Monosialylated | Monofunctional |
| GB3 | A | One domain | On | Monosialylated | NA | Monosialylated | Monofunctional |
| GB5 | B | Two domains | One | Nonsialylatedf | Monosialylated/disialylatedg | Offh | Off |
| MF6 | B | Two domains | On | Nonsialylated | Monosialylated/disialylated | Nonsialylated | Bifunctional |
| MF7 | B | Two domains | Off | Off | Monosialylated/disialylated | Off | Bifunctional |
| MF8 | B | Two domains | Off | Off | Monosialylated/disialylated | Monosialylated | Monofunctional |
| GB11 | A | One domain | On | Monosialylated | NA | Monosialylated | Monofunctional |
| GB16 | A | Two domains | On | Nonsialylated | NA | Nonsialylated | Bifunctional |
| GB17 | B | Two domains | On | Nonsialylated | Monosialylated/disialylated | Nonsialylated | Bifunctional |
| GB18 | A | One domain | On | Monosialylated | NA | Monosialylated | Monofunctional |
| GB19 | A | Two domains | On | Nonsialylated | NA | Nonsialylated | Bifunctional |
| MF20 | B | Two domains | On | Nonsialylated | Monosialylated/disialylated | Nonsialylated | Bifunctional |
| GB21 | A | One domain | On | Monosialylated | NA | Monosialylated | Monofunctional |
| GB22 | A | One domain | On | Monosialylated | NA | Monosialylated | Monofunctional |
| GB23 | A | One domain | On | Monosialylated | NA | Off | Monofunctional |
| GB25 | B | Two domains | On | Nonsialylated | Monosialylated/disialylated | Nonsialylated | Bifunctional |
| GB26 | A | Two domains | On | Nonsialylated | NA | Nonsialylated | Monofunctional |
| GB27 | A | Two domains | On | Nonsialylated | NA | Nonsialylated | Off |
| GB28 | A | One domain | On | Monosialylated | NA | Monosialylated | Monofunctional |
| GB31 | A | One domain | On | Monosialylated | NA | Monosialylated | Monofunctional |
Assignment of the glycosyltransferase variants is based on amino acid sequence comparisons with variants of known specificities (11, 12).
For CstII variants, monofunctional indicates that CstII has α-2,3-sialyltransferase activity, and bifunctional indicates that CstII has both α-2,3-sialyltransferase and α-2,8-sialyltransferase activity.
Monosialylated indicates that the glycosyltransferase is specific for the monosialylated acceptor.
NA, not applicable.
On indicates that a gene has no frameshift mutation.
Nonsialylated indicates that the glycosyltransferase is specific for a nonsialylated acceptor.
Monosialylated/disialylated indicates that the glycosyltransferase can use a monosialylated or a disialylated acceptor.
Off indicates that a gene is inactive because of a frameshift mutation.