FIG. 4.
Glucose absorption is decreased in response to C. parvum infection in macaques and is rectified after in vitro SP receptor (SPr) antagonist pretreatment. Glucose absorption was studied by the Ussing chamber technique using prechallenge jejunal biopsies and postchallenge biopsies from macaques, respectively, before and after C. parvum challenge and in postchallenge biopsies with and without SP receptor antagonist treatment. Changes in Isc (ΔIsc) induced by glucose are presented as maximal elevations in Isc and are expressed as μA/0.725 cm2. Bars represent mean values derived from data for three macaques. *, P < 0.05 (Student's t test for glucose-induced ΔIsc in postchallenge biopsies versus prechallenge biopsies); ‡, P < 0.05 (Student's t test for glucose-induced ΔIsc in postchallenge biopsies with and without SP receptor antagonist treatment).