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Silencing the expression of c-Cbl in endothelial cells enhances VEGFR-2-driven angiogenesis. PAE cells expressing either CKR alone or coexpressing c-Cbl-siRNA were prepared as spheroids and subjected to an in vitro angiogenesis/tubulogenesis as described in Fig. 5. Cells were either unstimulated, or stimulated with 40 ηg/ml CSF-1 (+CSF-1).
